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J FAS Int 2007;5:e3 - April 3, 2007
Mega-dose Vitamin C and E in Preventing FASD: The Decision to Terminate the Study Prematurely

Y Ingrid Goh1,2,3, Wendy Ungar3, Joanne Rovet4, Gideon Koren 1,2,3,5
1Motherisk Program, Division of Clinical Pharmacology & Toxicology, Hospital for Sick Children, Toronto, Ontario, 2Department of Pharmaceutical Sciences, University of Toronto, Toronto, Ontario, 3Department of Child Health Evaluative Studies, Hospital for Sick Children, Toronto, Ontario, 4Department of Psychology, Hospital for Sick Children, Toronto, Ontario, 5Department of Medicine, University of Western Ontario, London, Ontario.

Since 2004 we have been conducting a randomized control double blind trial on the favourable effect of mega-vitamin C and E in pregnant women with heavy alcohol exposure. The study was terminated in the summer of 2006 due to new evidence showing intrauterine growth restriction caused by such treatment in women with pre-eclampsia.

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