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Antimicrobial Therapy in Infants and Children

edited by Gideon Koren, Charles G. Prober, Ronald Gold. Marcel Dekker, Inc. 1988.

A summary of antibacterial, antifungal, antiviral and antiparasitic therapies in infants and children, this book explains underlying pharmacokinetic principles of antibiotic therapy, and includes recommendations for implementation and monitoring of drug therapy. Illustrated with useful diagrams and tables that summarize drug levels achieved in various tissues and levels needed for certain organisms, it is an essential clinical reference for pediatricians, microbiologists, infectious disease specialists and general practitioners.

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Contents: Introduction Foreward Preface Contributors		iv v vii xiii
	Part I General Principles
1.	Laboratory Procedures and the Management of Antimicrobial Therapy Donald E. Low	3
2.	Analytical Methods and Measurement of Antimicrobial Drugs H. Andrew Strong	19
3.	Clinical Relevance of Pharmacokinetic Principles for Antimicrobial Therapy Gideon Koren	33
	Part II Specific aspects of Antimicrobial Therapy in the Pediatric Age Group
4.	Clinical Pharmacology of Antimicrobial Drugs During Development: How Are Infants and Children Different? Gideon Koren	47
5.	Effect of Disease State and Organ Failure on Antimicrobial Disposition in Children James B. Besunder, Michael D. Reed and Jeffrey L. Blumer	53
6.	Therapeutic Drug Monitoring of Antimicrobial Drugs in Children Gideon Koren	77
7.	Exposure of the Embryo and Fetus to Antimicrobial Agents Gideon Koren	89
8.	Specific Problems Associated with Drug Administration in Neonates and Infants Mark Greenwald and Gideon Koren	99
9.	Compliance with Antimicrobial Therapy in Children Elaine Wang and R. Brian Haynes	105
	Part III Antibacterial Drugs
10.	Penicillins Susan M. Lisby and Milap C. Nahata	117
11.	Sulfonamides Michael D. Reed, James B. Besunder and Jeffrey L. Blumer	153
12.	Cephalosporins J. Steven Leeder and Ronald Gold	173
13.	Aminoglycosides Stuart M. MacLeod	237
14.	Vancomycin John F. Milliken	265
15.	Tetracyclines Daniel A. Goldstein	287
16.	Chloramphenicol Michael J. Rieder	311
17.	Macrolide Antibiotics Charles M. Ginsburg	339
18.	The Lincosamides Gideon Koren	355
19.	Rifampin Itamar Shalit	373
20.	Antituberculous Therapy E. Kanta Subbarao and Melvin I. Marks	405
21.	DNA-Gyrase Inhibitors Michael J. Muszynski, John C. Christenson and Ronald K. Scribner	433
22.	Nitrofurans Wayne M. Sullender	465
23.	Methenamine Pamela S. Diaz	475
24.	Antiseptics E. Lee Ford-Jones	483
	Part IV Antifungal Drugs
25.	Amphotericin B Allan S. Lau	517
26.	Imidazole Antifungals Alan M. Sugar	535
27.	5-Fluorocytosine Charles G. Prober	555
	Part V Antiviral Agents
28.	Vidarabine Therapy of Herpesvirus Infections in Childhood Richard J. Whitley	565
29.	Acyclovir Paul S. Lietman	577
30.	Ribavirin Charles G. Prober	587
31.	Interferon Ann M. Arvin	595
	Part VI Antiparasitic Drugs
32.	Antimalarial Drugs José Antonio Jesús Bodino and Eduardo L. López	607
33.	Antihelmintic Drugs José Antonio Jesús Bodino and Eduardo L. López	661
34.	Antifilarials José Antonio Jesús Bodino and Eduardo L. López	677
35.	Schistosomiasis Drugs José Antonio Jesús Bodino and Eduardo L. López	687
36.	Drugs Used in the Chemotherapy of Other Protozoal Infections José Antonio Jesús Bodino and Eduardo L. López	699
37.	Nitroimidazoles Edward D. Ralph	729
	Part VII Summary
38.	Drugs of Choice Charles G. Prober	749
39.	Guidelines for Intravenous Administration of Antimicrobial Drugs L. Lee Dupuis and Susan Stansfield	781
40.	Approaching Adverse Reactions to Antimicrobial Therapy in Children Neil H. Shear	793
index		805

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