- Morning Sickness
- Drugs in Pregnancy
- Alcohol, Nicotine, Substance Use
- Folic Acid
- Breastfeeding & Drugs
- Cancer in Pregnancy
- HIV and HIV Treatment
- Conditions in Pregnancy
- Infectious Diseases in Pregnancy
- Occupational & Environmental Exposures
- Pharmacokinetics/ Drug Metabolism
- The ReproPsych Group
- CAS Newsletter
1-877-327-4636 Alcohol and Substance
1-800-436-8477 Morning Sickness
1-888-246-5840 HIV and HIV Treatment
1-877-439-2744 Motherisk Helpline
416-813-6780 Motherisk Helpline
Pregnancy & Breastfeeding Resources
2013 FACE meeting
Fetal Alcohol Canadian Expertise (FACE) Satellite Meeting .
- Read more in our News Archive
Current Studies at Motherisk
Study seeks women between 4 and 12 weeks in their pregnancy with morning sickness (NVP)
Pregnancy in Women with Multiple Sclerosis
Environmental Exposures and Children's Health
Alcohol Use during Pregnancy
Control of Hypertension in Pregnancy Study
Folic Acid Before and During Pregnancy
Lamisil in Pregnancy
Meridia in Pregnancy
Autoimmune Diseases in Pregnancy Project
Motherisk Newsletters: Spring 2003, No. 17Spring 2003, No. 17
Exposure to Antidepressants Trazodone and Nefazodone Does Not Increase Risk of Birth Defects
Einarson A, Bonari L, Voyer-Lavigne S, Addis A, Matsui D, Johnson Y, Koren G.
A Motherisk study, published in the March 2003 issue of the scientific journal The Canadian Journal of Psychiatry, demonstrates that the use of trazodone and nefazodone does not increase the rates of major malformations, above the expected baseline rate of one to three per cent.
This is the first study to evaluate the safety of these drugs during pregnancy. The researchers were able to ascertain the outcomes of 147 pregnancies after exposure to trazodone or nefazodone from women in five different geographical centres. All of the women used the drugs during the first trimester, with 35 per cent taking them throughout their pregnancies.
Of the 147 pregnancies followed, there were 121 live births, 20 spontaneous abortions, and 6 therapeutic abortions. The group was compared to two control groups (one group was on other non-teratogenic antidepressants and the second group was exposed to other non-teratogenic drugs). Among the three groups, pregnancy outcomes did not differ except that there were more spontaneous abortions in both antidepressant groups. These findings may indicate that women with depression suffer more miscarriages and should be researched further.
"These study results empower health professionals to assist their pregnant patients in making informed decisions about antidepressant use during pregnancy," says Adrienne Einarson, the study's lead author and assistant director of the Motherisk Program. "Increasing evidence-based information should reassure women and their health professionals that the benefits of taking an antidepressant in pregnancy can largely outweigh any unproven risks."