• Home
  • Pregnancy &           
  • Bookshop
  • Contact us
  • Donate now
  • Frequently Asked Questions
  • Please read

Our Helplines

1-877-439-2744 Motherisk Helpline
1-800-436-8477 Morning Sickness
1-877-327-4636 Alcohol and Substance
1-866-937-7678 Exercise in Pregnancy
1-888-246-5840 HIV and HIV Treatment
416-813-6780 Motherisk Helpline

The Cancer in Pregnancy Forum

Archived Questions and Answers
This Forum has been the centre of an exceptional exchange of knowledge diagnosis, treatment, symptoms and other effects of cancer during pregnancy and lactation. All are welcome to review the Questions and Answers posted here, provided that they acknowledge and accept the important proviso and disclaimer below.
Submit a question
Forum > Chemotherapy: Maternal
Dose-modifications for antineoplastics during pregnancy

Date: 2003-05-22

Dosing of antineoplastic drugs during pregnancy:

Several reviews exist in which possible changes in the pharmacokinetics of antineoplastic agents are described (Volume of distribution, Clearance, amniotic fluid as a "third space" etc.). Are there any recommendations or dose-modifications for antineoplastics during pregnancy with respect to the above mentioned pharmacokinetic changes? Is the current body-weight or the weight before pregnancy used for calculation of body-surface ?

Pregnancy is indeed associated with various pharmacokinetic changes. Even with regard to non-cancer conditions, very few drugs have been formally compared in pregnancy vs. postpartum. Presently we are not aware of any such studies with cancer chemotherapy in pregnancy. Consequently, there are no changes in dose guidelines for pregnancy. One may hypothesize that for most agents, either renally or hepatically eliminated, levels in pregnancy will be lower and potentially, effect may decrease.

Valid XHTML 1.0 Transitional [Valid RSS]

* - "MOTHERISK - Treating the mother - Protecting the unborn" is an official mark of The Hospital for Sick Children. All rights reserved.

The information on this website is not intended as a substitute for the advice and care of your doctor or other health-care provider. Always consult your doctor if you have any questions about exposures during pregnancy and before you take any medications.

Copyright © 1999-2015 The Hospital for Sick Children (SickKids). All rights reserved.

The Hospital for Sick Children (SickKids) is a health-care, teaching and research centre dedicated exclusively to children; affiliated with the University of Toronto. For general inquires please call: 416-813-1500.

  |  Contact SickKids  |  Terms of Use