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This Forum has been the centre of an exceptional exchange of knowledge diagnosis, treatment, symptoms and other effects of cancer during pregnancy and lactation. All are welcome to review the Questions and Answers posted here, provided that they acknowledge and accept the important proviso and disclaimer below.
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Forum > Chemotherapy: Maternal
Effects of chemo before pregnancy and within first trimester

Date: 2004-01-03

29 yo lady treated for Acute Promyelocytic Leukemia with Idaubicin and ATRA between the period of Jan to Oct/03. Last chemotherapy received Oct 12/03 where she completed 6 monthly doses of Idarubicin and ATRA (all transretinoic acid). Now pregnant of 6 wks. We were planning to put her on maintenance of oral 6-MP and methotrexate prior to her getting pregnant. What would your advise be? What would the consequences be having been exposed to the above chemotherapy 1-2 months before getting pregnant? Thank you

Exposure to the medications in question, or any other human chemotherapy, 2 to 3 months before conception has not been associated with malformations. If the maintenance with 6MP and MTX is deemed clinically important, they should be avoided in the first trimester.

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