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The Cancer in Pregnancy Forum

Archived Questions and Answers
This Forum has been the centre of an exceptional exchange of knowledge diagnosis, treatment, symptoms and other effects of cancer during pregnancy and lactation. All are welcome to review the Questions and Answers posted here, provided that they acknowledge and accept the important proviso and disclaimer below.
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Forum > Chemotherapy: Maternal
Docetaxel in Pregnancy

CCoPE
Date: 2001-01-02

Question:
I have a question about a patient who is currently taking docetaxel and is 5 weeks pregnant. The physician asking the question is wondering about any ill affects associated with the drug and pregnancy. I have searched Medline, the internet, the product monograph, Briggs, called your information line and micromedex. Do you have any experience or other information about this drug in pregnancy. Thank you for your help.

Answer:
While there is no human data on docetaxel in pregnancy, both this drug and its relative paclitaxel, are highly embryotoxic in animals. The sixth week of gestation is extremely sensitive to teratogenicity, as numerous organs are produced. It is very probable that this woman has higher than baseline risk for birth defects. It is important to ensure that she understand this risk and make informed decisions. If pregnancy is continued, close monitoring of fetal well-being and detailed ultrasound for visible malformations should be conducted. A high risk obstetric unit should be involved. Please update us, so we can help other women.

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