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The Cancer in Pregnancy Forum

Archived Questions and Answers
This Forum has been the centre of an exceptional exchange of knowledge diagnosis, treatment, symptoms and other effects of cancer during pregnancy and lactation. All are welcome to review the Questions and Answers posted here, provided that they acknowledge and accept the important proviso and disclaimer below.
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Forum > Chemotherapy: Maternal
Handling chemotherapeutic agents

Date: 2003-02-10

Is there any information available on the potential effects on fetal development for a pregnant research scientist working in a laboratory growing human cancer cell lines in vitro, followed by administration of chemotherapeutic agents or transplantation into mice? This work will persist for the duration of the pregnancy, involves preparation of concentrated drug stocks such as doxorubucin, docetaxel, paclitaxel and methotrexate, treatment of in vitro cell cultures, followed by measurement of cytotoxicity with further potentially mutagentic compounds used in the MTT and SRB assays. Organic solvents such as DMSO will also be used for drug solubilization and in the cytoxicity assays. If all procedures are carried out in tissue culture and standard fumehoods, are there any risks to the baby? Thank you kindly for your help in this matter.

Handling of all chemotherapeutic agents and organic solvents should be done under the fumehood while wearing a mask. If these recommendations are followed there should not be any discernible fetal exposure.

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