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Retinoids in Clinical Practice ; The Risk-Benefit Ratio

(G. Koren, Ed). Marcel Dekker, NY 1993.

edited by Gideon Koren. Marcel Dekker, Inc. 1993.

A review of the elements involved in the risk-benefit ratio of retinoids, a unique and potent group of pharmacological agents. Written to help clinicians, ethicists, scientists, the pharmaceutical industry and regulatory agencies understand the complexities underlying the risk-benefit ratio of unique but highly teratogenic drugs.

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Contents:


Introduction
Preface
Contributor




iii
v
ix
1. Therapeutic Efficacy of Retinoids
J.A.J. Kovacs and Neil H. Shear
1
2. Vitamin A in the Fetus and Newborn
Rafael Gorodischer
37
3. Developmental Toxicology of Retinoids
Narsingh D. Agnish and Devendra M. Kochhar
47
4. Retinoid Embryopathy in Humans
Franz W. Rosa
77
5. Neural and Behavioral Pathology Following PrenatalExposure to Retinoids
Jane Adams
111
6. Clinical Relevance of Retinoid Parmacokinetics
Julia Klein, Anne L. Pastuszak and Gideon Koren
129
7. The Retinoid Pregnancy Prevention Program
Anne L . Pastuszak and Gideon Koren
147
8. Analysis of Contraception Failure in Canadian Women Treated with Systemic Retinoids
Anne L. Pastuszak and Gideon Koren
177
9. A New Approach to Counseling Women on Their Teratogenic Risk
Gideon Koren
201
10. Retinoid Embryopathy: Epidemiological Perspectives
Donald L. Kaiser
209
11. Regulatory Evolution: Approach to the Marketing of a Known Teratogen, Isotretinoin (Accutane)
Michèle Brill-Edwards and Celia Viets
225
12. Adverse Nonreproductive Effects of Retinoids in Humans
J.A.J. Kovacs and Neil H. Shear
241
13. Isotretinoin Benefits and Risks: Assessment of the Ratio
Gideon Koren
261
index 267
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