1-877-439-2744 Motherisk Helpline
1-800-436-8477 Morning Sickness
1-877-327-4636 Alcohol and Substance
1-866-937-7678 Exercise in Pregnancy
1-888-246-5840 HIV and HIV Treatment
416-813-6780 Motherisk Helpline
Pregnancy & Breastfeeding Resources
Current Studies at Motherisk
The Safety of Diclectin in Breastfeeding
Neurodevelopment of Children Exposed in-Utero to Chemotherapy for Maternal Breast Cancer (Dr. I Nulman)
Diclegis Surveillance Program Study
Diclectin Surveillance Program Study
Study seeks women between 4 and 12 weeks in their pregnancy with morning sickness (NVP)
Pregnancy in Women with Multiple Sclerosis
Alcohol Use during Pregnancy
Lamisil in Pregnancy
Meridia in Pregnancy
Autoimmune Diseases in Pregnancy Project
Cancer in Pregnancy: Hepatocellular Carcinoma in Pregnancy
Hepatocellular carcinoma (HCC) in pregnancy is very rare. Lau et al reviewed the published literature between 1957 and 1993 of this association and found 28 cases1. They also reported an association between high parity 1, HBsAg carriers 1,3, oral contraceptives 1,2 and HCC appearances. Focused medical history and the level of serum AFP may be helpful as screening tools 1.
Most patients complain of right upper quadrant pain or distention and weight loss. An irregular liver mass together with excessively high serum a-fetoprotein (AFP) level suggest HCC 4. AFP may also be used for screening HCC in pregnant women at high risk. Liver sonography and/or magnetic resonance imaging together with fine liver aspiration of the liver are used for definite diagnosis during pregnancy 1,5.
Although a shorter median survival for pregnant women with HCC has been suggested 1 we believe that the small number of published cases precludes any firm conclusions. Two case reports of HCC diagnosed in the second trimester reported favorable outcomes for both mother and child 2,6.
- Lau WY, Leung WT, Ho S, Lam SK, Johnson PJ, Williams R, Li AK. Hepatocellular carcinoma during pregnancy and its comparison with other pregnancy associated malignancies. Cancer 75:2669-75, 1995.
- Gisi P, Floyd R. Hepatocellular carcinoma in pregnancy. A case report. J Reprod Med 1999 Jan;44(1):65-7.
- T'Sang-T'ang Hsien, Hong-Chih Hou et al. Term delivery after hepatocellular carcinoma resection in previous pregnancy. Acta Obstet Gynecol Scand 1996;75:77-8.
- To WK, Ghosh A. Primary liver carcinoma complicating pregnancy. Aust. and N.Z. J. of Obstet & Gynecol 33:325-6, 1993.
- Entezami M, Becker R, Ebert A, Pritze W, Weitzel H. Case report: Hepatocellular carcinoma as a rare case of an excessive increase of a-fetoprotein during pregnancy. Gyncol Oncol 62:405-7, 1996.
- To WK, Ghosh A. Primary liver carcinoma complicating pregnancy. Aust NZ J Ostet Gynecol 1993 Aug;33(3):325-6.