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Pregnancy & Breastfeeding Resources
Current Studies at Motherisk
Study seeks women between 4 and 12 weeks in their pregnancy with morning sickness (NVP)
Pregnancy in Women with Multiple Sclerosis
Environmental Exposures and Children's Health
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Cancer in Pregnancy: Pentostatin
Pentostatin (Deoxycoformycin; Covidarabine) is a potent non-competitive inhibitor of adenosine deaminase. Pentostatin is used in the treatment of lymphoproliferative malignancies, particularly hairy cell leukemia.
|Animal studies *||mouse||5 mg/kg||In mice the mode of action is via abnormal development of the allantois 1. Using 5 mg/kg on day 7, defects of neural tube closure and arch development were found on day 10 and followed by a high rate of embryonic loss 2|
|rabbit||up to 0.02 mg/kg daily.||In the rabbit fetal toxicity occurred after intravenous administration but no teratogenicity 3. Fuchigami et al (1991) gave up to 0.1 mg/kg intravenously and found fetal death and toxicity at 0.02 mg per kg but no teratogenicity. 4|
|rats||0.75 mg/kg||In rats fetal resorptions were increased and body weight reduced along with skeletal abnormalities and defects 3.|
|mice||up to 1 mg/kg||Deficiency in spleen and thymus weight has been noted after perinatal treatment of mice with deoxycoformycin 5. All pups from dams treated during the last 5 days of pregnancy with deoxycoformycin died within 2 days of birth; however, treatment during embryogenesis had no effect on pup survival.|
|Human studies||No epidemiological studies of congenital anomalies in infants born towomen treated with dacarbazine during pregnancy have been reported.|
- Airhart, M.J.; Robbins, C.M.; Knudsen,T.B.; Church, J.K. and Skalko, R.G.: Developing allantois is a primarysite of 2'-deoxxycoformycin toxicity. Teratology 53:361-373, 1996.
- Airhart, M.J.; Robbins, C.M.; Knudsen, T.B.; Church, J.K. and Skalko, R.G.: Occurrence of embryotoxicity in mouse embryos following in utero exposure to 2'-deoxycoformycin (pentostatin). Teratology 47:17-27,1993.
- Dostal, L.A.; Brown, S.; Bleck, J. andAnderson, J.A.: Developmental toxicity of pentostatin (2'-deoxycoformycin) in rats and rabbits. Teratology 44:325-334, 1991.
- Fuchigami, K.; Sameshima, K.; Izumi, H.;Honda, H.; Yamauchi, M.; Hayashida, M.; Inoue, H.; Kuwata, S.; Umehashi, M. and Shigaki, T.: Study by intravenous administration of YK-176 during the period of organogenesis in rabbits. The Clinical Report 25:4319-4327, 1991.
- Luebke RW et al: Immune function in mice exposed to the adenosine deaminase inhibitor 2'-deoxycoformin during immune system development. Immunopharmacol Immunotoxicol 9:149-61, 1987.