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Acid Suppressing Drugs

Treatment of heartburn and acid reflux associated with nausea and vomiting during pregnancy

Ruth Law, Caroline Maltepe, Pina Bozzo and Adrienne Einarson, RN

February 2010

ABSTRACT

QUESTION

In addition to suffering from nausea and vomiting of pregnancy, which is being treated with antiemetics, some of my pregnant patients complain of heartburn and acid reflux. Should these symptoms also be treated and, if so, which acid-reducing medications are safe for use during pregnancy?

ANSWER

Increased severity of nausea and vomiting of pregnancy is associated with the presence of heartburn and acid reflux. Antacids, histamine-2 receptor antagonists, and proton pump inhibitors can be used safely during pregnancy, as large studies have been published with no evidence of adverse fetal effects.

QUESTION

En plus de souffrir de la nausée et des vomissements de la grossesse, des malaises traités à l'aide d'antiémétiques, certaines de mes patientes enceintes se plaignent de brûlures d'estomac et de reflux acides. Devrait-on aussi traiter ces symptômes et, dans l'affirmative, quels sont les médicaments contre l'hyperacidité qui sont sans risque durant la grossesse?

RÉPONSE

La gravité accrue de la nausée et des vomissements est associée à la présence de brûlures d'estomac et de reflux acides. Les antiacides, les antagonistes du récepteur H2 de l'histamine et les inhibiteurs de la pompe à protons peuvent être utilisés en toute sécurité durant la grossesse, puis que d'importantes études publiées ne révèlent pas de données factuelles à l'effet qu'ils causeraient des effets indésirables chez le fœtus

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