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Pregnancy & Breastfeeding Resources
Current Studies at Motherisk
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Study seeks women between 4 and 12 weeks in their pregnancy with morning sickness (NVP)
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Pregnancy in Women with Multiple Sclerosis
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Environmental Exposures and Children's Health
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Alcohol Use during Pregnancy
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Control of Hypertension in Pregnancy Study
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Folic Acid Before and During Pregnancy
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Lamisil in Pregnancy
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Meridia in Pregnancy
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Autoimmune Diseases in Pregnancy Project
Dextromethorphan
Dextromethorphan: Extrapolation of findings from reproductive studies in animals to humans
Adrienne Einarson, RN; Gideon Koren, MD, FRCPCOctober, 1999
QUESTION
One of my patients, who is now 8 weeks pregnant, just read in the newspaper that dextromethorphan (DM), an antitussive found in a variety of cough medicines, caused birth defects in chicken embryos. The author of the study stated that even one dose could be dangerous and that he would never allow his wife to use this drug if she were pregnant. My patient was understandably very concerned because last week she was suffering from a nasty cough and had been advised by her pharmacist to use a cough mixture containing DM, which she subsequently took for several days.
ANSWER
You may reassure your patient that she did not put her baby at risk by using this substance. Dextromethorphan has been on the market for many years and has never been implicated as a human teratogen. Furthermore, chick embryos are not a good model for predicting teratogenic potential in humans and, consequently, were abandoned as such more than 30 years ago.
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