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Ribavirin-Interferon Alpha 2B

Paternal use of ribavirin-interferon alpha 2B combination therapy before conception

Nobuko Taguchi, MD Shinya Ito, MD

December 2005

ABSTRACT

QUESTION

One of my male patients is receiving ribavirin-interferon alpha 2B (Pegetron) combination therapy for chronic hepatitis C. His wife recently found out she is 6 weeks pregnant. They are concerned that the medications might have affected his sperm. How should I advise them?

ANSWER

To the best of our knowledge, paternal exposure to ribavirin-interferon alpha 2B has no adverse effects on reproduction. Although we do not have sufficient information to confirm this, several pregnancies where the father had been exposed to these medications turned out fine. If an unexpected pregnancy occurs while the father is receiving this therapy, there is no medical indication for terminating the pregnancy.

QUESTION

L'un de mes patients reçoit une thérapie combinée de ribavirine et d'interferon alpha 2B (Pegetron) pour une hépatite C chronique. Sa conjointe vient d'apprendre qu'elle est enceinte de 6 semaines. Ils s'inquiètent de l'effet de ces médicaments sur le sperme. Quels conseils devrais-je leur donner?

RÉPONSE

Au meilleur de notre connaissance, l'exposition paternelle à la ribavirine-interferon alpha 2B n'a pas d'effet indésirable sur la reproduction. Même si nous n'avons pas suffisamment de renseignements pour le confirmer, plusieurs grossesses où le père avait été exposé à ces médicaments n'ont pas eu d'issue défavorable. Si une grossesse imprévue survient pendant que le père reçoit cette thérapie, il n'y a pas d'indication médicale justifiant de mettre un terme à cette grossesse.

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