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Exposure to sibutramine during pregnancy

Facundo Garcia-Bournissen MD, Alon Shrim MD, Gideon Koren MD FRCPC

February 2007



One of my patients who was taking sibutramine to lose weight found out that she had unexpectedly conceived. The medication was stopped as soon as she found out, about 5 weeks into the pregnancy. Is the baby at risk? Should the pregnancy be aborted?


No data to date suggest that involuntary exposure to sibutramine during pregnancy carries major risk of congenital malformations. Nevertheless, this medication should be avoided whenever possible during pregnancy, as there is little information on its effects.


L’une de mes patientes prenait de la sibutramine pour perdre du poids, quand elle s’est rendu compte de sa grossesse imprévue. Elle a cessé ses médicaments aussitôt qu’elle a su qu’elle était enceinte, à environ 5 semaines de gestation. Le fœtus est-il à risque? Faudrait-il mettre un terme à la grossesse?


Aucune donnée jusqu’à présent ne laisse entendre qu’une exposition involontaire à la sibutramine durant la grossesse entraîne un risque majeur de malformations congénitales. Par contre, ce médicament devrait être évité dans la mesure du possible pendant la grossesse compte tenu de la rareté des renseignements concernant ses effets.

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