1-877-439-2744 Motherisk Helpline
1-800-436-8477 Morning Sickness
1-877-327-4636 Alcohol and Substance
1-866-937-7678 Exercise in Pregnancy
1-888-246-5840 HIV and HIV Treatment
416-813-6780 Motherisk Helpline
Pregnancy & Breastfeeding Resources
Current Studies at Motherisk
The Safety of Diclectin in Breastfeeding
Neurodevelopment of Children Exposed in-Utero to Chemotherapy for Maternal Breast Cancer (Dr. I Nulman)
Diclegis Surveillance Program Study
Diclectin Surveillance Program Study
Study seeks women between 4 and 12 weeks in their pregnancy with morning sickness (NVP)
Pregnancy in Women with Multiple Sclerosis
Alcohol Use during Pregnancy
Lamisil in Pregnancy
Meridia in Pregnancy
Autoimmune Diseases in Pregnancy Project
The Motherisk Nausea and Vomiting of Pregnancy (NVP) ForumMotherisk receives questions from around the world about morning sickness symptoms, effects, treatments and ways to cope. Those questions and answers are posted here for anyone to read, provided the reader acknowledges and accepts the proviso and disclaimer below.
I am the mother of a 2 year old, and am considering getting pregnant again in the near future. I had hyperemesis (severe NVP) throughout my first pregnancy, and required IV fluids for 2 mos. I was treated with Zofran, and that finally stopped the vomiting after a few weeks. Are there any studies showing risk factors in using Zofran in the first trimester? Have any newer medications been tried in the past few years? Also, I have seen studies indicating that the presence of h.pylori has also been linked to morning sickness. Can you comment on how this is impacting your treatment of NVP? Thank you!
We're so glad you asked about Zofran. Motherisk has just started a study to investigate the safety and efficacy of Zofran (ondansetron) during pregnancy. Since it is a prospective study, only women who are currently pregnant and have used or are using the drug to treat nausea and vomiting are eligible to enroll. Participation involves an initial interview and another follow-up interview 4 to 6 months after the baby is born. The interviews are conducted over the phone, are strictly confidential and take approximately 20 minutes to complete. For more information about this study or other medications for NVP, please call our NVP counsellor. The call is free: 1-800-436-8477.