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The Motherisk Nausea and Vomiting of Pregnancy (NVP) Forum

Motherisk receives questions from around the world about morning sickness symptoms, effects, treatments and ways to cope. Those questions and answers are posted here for anyone to read, provided the reader acknowledges and accepts the proviso and disclaimer below.

Forum > Hyperemesis Gravidarum: Treating HG
Cyproheptadine

Hyperemesis Gravidarum
Date: 1999-12-13

Question:
Is there any information about the use of cyproheptadine in use of hyperemesis gravidarum?

Answer:
No. Animal studies have shown that cyproheptadine crosses the placenta and causes damage to the pancreas. One human study conducted in the 1970's looked at the use of cyproheptadine to prevent consecutive miscarriages. To our knowledge, however, this drug has never been used to treat nausea and vomiting of pregnancy.

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